Gx G-Fix Standard Adapter
Interface between Syringe and Device
The development of autoinjectors generally involves the integration of a prefilled glass syringe into a plastic drug delivery device – a major challenge due to the different tolerances of both materials. Gerresheimer AG, Düsseldorf, Germany, has now filed a patent application for its Gx G-Fix standard adapter for precise and reliable positioning of syringes and needle shields.
Most autoinjectors contain two main modules: the injector itself and the prefilled syringe. Both modules are combined in one assembly, which is specified by the pharmaceutical company and supplied to the market in one piece. This approach is important as medical technology products are subject to high quality standards and must be reliable. In practice, however, the production of autoinjectors has to deal with the tolerance requirements of two entirely different materials: the device is made of plastic while the prefilled syringe is made of glass.
Gerresheimer has created an interface that works without complex two-component injection molded parts or sophisticated assembly processes. Attached to the syringe shoulder, the plastic standard adapter provides a precisely defined interface to the device. In the auto injector, Gx G-Fix has several functions. First, the adapter connects the syringe with the device. As Gx G-Fix is specifically adapted to the autoinjector, it allows accurate needle positioning and significantly higher control of the injection process.
Second, the syringe is well protected from breaking. With Gx G-Fix, attaching the syringe at the sturdier shoulder has minimized the risk of breakage substantially. Moreover, Gx G-Fix allows a precisely defined distance to the rigid needle shield (RNS). As most autoinjectors are equipped with long 1ml syringes, tolerances often result in a repositioning of the RNS either towards the front or towards the rear, which means that RNS removal requires autoinjector caps with a complex design. This problem can be solved by using a variation of the adapter that connects with the RNS. With a clearly defined position, RNS removal no longer requires a specific design of the injector cap.
The Gx G-Fix is assembled as part of the ready-to-fill syringe processing at the syringe manufacturer’s facility. Device integration and RNS positioning with Gx G-Fix can be used individually or in combination. Plastic syringes can also be easily fitted with the adapter. Autoinjectors with Gx G-Fix are therefore suitable for plastic and glass syringes and can therefore be used for a variety of drugs. This does not require any changes to the customer’s filling station.
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