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03-01-2018

New U.S. Government Study Supports Bisphenol A Safety

Clean Bill of Health for Currently Authorized BPA Uses

Last week, the U.S. government released its Draft Report with results from the largest study ever conducted on bisphenol A (BPA). The results of the study, which is the key part of a multi-year in-depth research program, strongly support the safety of BPA.

The U.S. Food and Drug Administration (FDA) has routinely considered and evaluated the scientific evidence surrounding the use of BPA and has published a draft report on the findings of a comprehensive two-year rodent study examining the potential effects of BPA on health. The study was conducted by senior scientists at the FDA’s National Center for Toxicological Research (NCTR). The study is part of a collaborative effort called the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA), which was established by the FDA and the National Institute of Environmental Health Sciences (NIEHS) of the National Institutes of Health after a 2008 NTP report raised some concerns about developmental effects in rodents exposed to relatively low doses of BPA.

"Minimal Effects" after BPA Exposure

The core study was designed to look at the effects of several different doses of BPA evaluating chronic and early life exposure in two different groups of rodents. The doses ranged from low doses that would be comparable to typical human exposures, to doses that vastly exceed human exposures. A variety of endpoints were evaluated including growth, weight and tumor development. Overall, the study found “minimal effects” for the BPA-dosed groups of rodents. The report did identify some areas that may merit further research, such as the increase in occurrence of mammary gland tumors at one of the five doses, in one of the groups. But the significance of these findings will be assessed through the peer review process.

Safe for Consumers

In an FDA statement , Stephen Ostroff M.D., Deputy Commissioner for Foods and Veterinary Medicine, says that "our initial review supports our determination that currently authorized uses of BPA continue to be safe for consumers". Steven G. Hentges, Ph.D., Polycarbonate/BPA Global Group of the American Chemistry Council (ACC) commented: "The results of the CLARITY Core study once again demonstrate that BPA is safe at the very low levels to which people are typically exposed. This study is the largest study ever conducted on BPA, and the results indicate that BPA has very little potential to cause health effects even when people are exposed to it throughout their lives.” He added: “We now look forward to updated safety conclusions from regulatory authorities worldwide who have been awaiting the study results."

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