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Kunststoffe international 2015/04

Packaging and Storage of Biopharmaceutical Products

Multilayer Plastic Vials Provide Good Barrier Properties and Increased Impact Resistance

Packaging and Storage  of Biopharmaceutical Products

Biopharmaceutical medications on peptide and protein base cannot be administered orally, because, due to their similarity to food, they will be degraded inefficiently at the digestive system. So normally they are given as injectable solved agents or intravenous drip. A big task is to find suitable materials for packaging.

Dr. rer. nat. Wolfgang Dirk

Beitrag auf Deutsch lesen
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Literature

1 Biological Drug Delivery 2007-2012. Visiongain Ltd, London, United Kingdom

2 Prefilled Syringes – 2009 Drugs, Devices and Disease Therapeutics. Greystone Associates, Amherst, NH, USA

3 Wu, C.-S.; et al: Adsorption of proteins onto glass surfaces and its effects on the intensity of circular dichroism spectra. Analytical Biochemistry 177 (1989), pp. 178-182

4 Jones, L.; Kaufmann, A.; Middaugh, C.R.: Silicone oil induced aggregation of proteins. Journal of Pharmaceutical Sciences 94 (2005) 4, pp. 918-927

5 Burke, C.J.; Steadman, B.L.; Volkin, D.B.; Tsai, P.K.; Bruner, M.W.; Middaugh, C.R.: The adsorption of proteins topharmaceutical container surfaces. International Journal of Pharmaceutics 86 (1992), pp. 89-93

6 Qadry, S.S.; Roshdy, T.H.; Char, H.; Del Terzo, S.; Tarantino, R.; Moschera, J.: Evaluation of COP vials for packaging protein-based parenteral formulations. International Journal of Pharmaceutics 252 (2003), pp. 207-212

7 Bloomfield, J.E.; Merck Sharp & Dohme Corp, a subsidiary of Merck & Co, Inc, at the 2011 PDA/FDA Glass Quality Conference, Arlington, VA, 23rd to 24th May, 2011

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